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Article

Increased burden of rare variants in genes of the endosomal Toll-like receptor pathway in patients with systemic lupus erythematosus.

Lupus - 1 Oct 2021

Lea-Henry Tom N, Chuah Aaron, Stanley Maurice, Athanasopoulos Vicki, Starkey Malcolm R, Christiadi Daniel, Kitching A Richard, Cook Matthew C, Andrews Thomas D, Vinuesa Carola G, Walters Giles D, Jiang Simon H

Abstract excerpt

OBJECTIVE: To compare the frequency of rare variants in genes of the pathophysiologically relevant endosomal Toll-like receptor (eTLR) pathway and any quantifiable differences in variant rarity, predicted deleteriousness, or molecular proximity in patients with systemic lupus erythematosus (SLE) and healthy controls. PATIENTS AND METHODS: 65 genes associated with the eTLR pathway were identified by literature...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34266320
DOI: 10.1177/09612033211033979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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