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Article

Genetic evidence supporting potential causal roles of EIF4 family in breast cancer: a two-sample randomized Mendelian study.

Scientific reports - 30 Aug 2024

Shi Jin-Yu, Wen Rui, Chen Jin-Yi, Feng Yi-Qian, Zhang Yuan-Yuan, Hou Si-Jia, Xi Yu-Jia, Wang Jiang-Fen, Zhang Ya-Fen

Abstract excerpt

Translational control plays a crucial role in the regulation of apoptosis, with the EIF4 family serving as one of the mRNA translation factors that modulate the process of mRNA translation based on mRNA characteristics. To address this potential causal role of EIF4 family proteins and breast cancer, Mendelian randomization was employed. The study incorporated four sets of genetics instrumental variables, namely...

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Identifiers

PMID: 39215053
DOI: 10.1038/s41598-024-71059-1
PMCID: PMC11364806

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