Article
A live attenuated cold-adapted influenza A H7N3 virus vaccine provides protection against homologous and heterologous H7 viruses in mice and ferrets.
Virology - 15 Aug 2008
Joseph Tomy, McAuliffe Josephine, Lu Bin, Vogel Leatrice, Swayne David, Jin Hong, Kemble George, Subbarao Kanta
Abstract excerpt
The appearance of human infections caused by avian influenza A H7 subtype viruses underscores their pandemic potential and the need to develop vaccines to protect humans from viruses of this subtype. A live attenuated H7N3 virus vaccine was generated by reverse genetics using the HA and NA genes of a low pathogenicity A/chicken/BC/CN-6/04 (H7N3) virus and the six internal protein genes of the cold-adapted A/Ann...
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