Catechol-O-methyltransferase gene polymorphisms in benign prostatic hyperplasia and sporadic prostate cancer.

doi:10.1158/1055-9965.EPI-05-0550

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Article

Catechol-O-methyltransferase gene polymorphisms in benign prostatic hyperplasia and sporadic prostate cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2006

Tanaka Yuichiro, Sasaki Masahiro, Shiina Hiroaki, Tokizane Takashi, Deguchi Masao, Hirata Hiroshi, Hinoda Yuji, Okayama Naoko, Suehiro Yutaka, Urakami Shinji, Kawakami Toshifumi, Kaneuchi Masanori, Pookot Deepa, Igawa Mikio, Okuyama Akihiko, Ishii Nobuhisa, Dahiya Rajvir

Abstract excerpt

Various carcinogenic metabolites, including catechol estrogens, play a role in malignant transformation. An enzyme that is capable of neutralizing the genotoxic effects of these compounds is catechol-O-methyltransferase (COMT). A variant form of this enzyme has been shown to reduce its activity by up to 4-fold; thus, we hypothesize that single nucleotide polymorphisms of the COMT gene can be a risk factor for...

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PMID: 16492910
DOI: 10.1158/1055-9965.EPI-05-0550

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COMT

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Catechol-O-methyltransferase gene polymorphisms in benign prostatic hyperplasia and sporadic prostate cancer.PMID 16492910Read ↗

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