Article
Role of S128R polymorphism of E-selectin in colon metastasis formation.
International journal of cancer - 1 Aug 2007
Alessandro Riccardo, Seidita Gregorio, Flugy Anna Maria, Damiani Francesca, Russo Antonio, Corrado Chiara, Colomba Paolo, Gullotti Lucia, Buettner Reinhard, Bruno Loredana, De Leo Giacomo
Abstract excerpt
The extravasation of cancer cells is a key step of the metastatic cascade. Polymorphisms in genes encoding adhesion molecules can facilitate metastasis by increasing the strength of interaction between tumor and endothelial cells as well as impacting other properties of cancer cells. We investigated the Ser128Arg (a561c at the nucleotide level) polymorphism in the E-selectin gene in patients with metastatic colon...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
