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Article

The C. elegans sex determination gene laf-1 encodes a putative DEAD-box RNA helicase.

Developmental biology - 15 Jun 2009

Hubert Amy, Anderson Philip

Abstract excerpt

The Caenorhabditis elegans gene laf-1 is critical for both embryonic development and sex determination. Laf-1 is thought to promote male cell fates by negatively regulating expression of tra-2 in both hermaphrodites and males. We cloned laf-1 and established that it encodes a putative DEAD-box RNA helicase related to Saccharomycescerevisiae Ded1p and Drosophila Vasa. Three sequenced laf-1 mutations are missense...

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Source

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Identifiers

PMID: 19361491
DOI: 10.1016/j.ydbio.2009.04.003
PMCID: PMC2802855

Genes

TRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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