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Article

A Caenorhabditis elegans TGF-beta, DBL-1, controls the expression of LON-1, a PR-related protein, that regulates polyploidization and body length.

The EMBO journal - 1 Mar 2002

Morita Kiyokazu, Flemming Anthony J, Sugihara Yukiko, Mochii Makoto, Suzuki Yo, Yoshida Satoru, Wood William B, Kohara Yuji, Leroi Armand M, Ueno Naoto

Abstract excerpt

Using cDNA-based array analysis combined with double-stranded RNA interference (dsRNAi), we have identified yk298h6 as a target gene of Caenorhabditis elegans TGF-beta signaling. Worms overexpressing dbl-1, a TGF-beta ligand, are 16% longer than wild type. Array analysis shows yk298h6 to be one of several genes suppressed in such worms. Disruption of yk298h6 function by dsRNAi also resulted in long worms,...

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Identifiers

PMID: 11867534
DOI: 10.1093/emboj/21.5.1063
PMCID: PMC125886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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