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Article

Mechanism of beta clamp opening by the delta subunit of Escherichia coli DNA polymerase III holoenzyme.

The Journal of biological chemistry - 1 Jun 2001

Stewart J, Hingorani M M, Kelman Z, O'Donnell M

Abstract excerpt

The beta sliding clamp encircles the primer-template and tethers DNA polymerase III holoenzyme to DNA for processive replication of the Escherichia coli genome. The clamp is formed via hydrophobic and ionic interactions between two semicircular beta monomers. This report demonstrates that the beta dimer is a stable closed ring and is not monomerized when the gamma complex clamp loader...

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Identifiers

PMID: 11279099
DOI: 10.1074/jbc.M100592200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mechanism of beta clamp opening by the delta subunit of Escherichia coli DNA polymerase III holoenzyme.PMID 11279099Read ↗

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