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Coagulation factor VIII: biological basis of emerging hemophilia A therapies

1 Aug 2024

Abstract excerpt

ABSTRACT: Coagulation factor VIII (FVIII) is essential for hemostasis. After activation, it combines with activated FIX (FIXa) on anionic membranes to form the intrinsic Xase enzyme complex, responsible for activating FX in the rate-limiting step of sustained coagulation. Hemophilia A (HA) and hemophilia B are due to inherited deficiencies in the activity of FVIII and FIX, respectively. Treatment of HA over the...

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PMID: 39088776
DOI: 10.1182/blood.2023023275

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