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Article

Mutating factor VIII: lessons from structure to function.

Blood reviews - 1 Jan 2005

Fay Philip J, Jenkins P Vincent

Abstract excerpt

Factor VIII, a metal ion-dependent heterodimer, circulates in complex with von Willebrand factor. At sites of vessel wall damage, this procofactor is activated to factor VIIIa by limited proteolysis and assembles onto an anionic phospholipid surface in complex with factor IXa to form the intrinsic factor Xase; an enzyme complex that efficiently converts factor X to factor Xa during the propagation phase of...

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Identifiers

PMID: 15572214
DOI: 10.1016/j.blre.2004.02.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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