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Article

Major role for hypoxia inducible factor-1 and the endothelin system in promoting myocardial infarction and hypertension in an animal model of obstructive sleep apnea.

Journal of the American College of Cardiology - 14 Apr 2009

Belaidi Elise, Joyeux-Faure Marie, Ribuot Christophe, Launois Sandrine H, Levy Patrick, Godin-Ribuot Diane

Abstract excerpt

OBJECTIVES: Our aim was to investigate the involvement of the endothelin (ET) system in the cardiovascular consequences of intermittent hypoxia (IH). BACKGROUND: Obstructive sleep apnea (OSA) syndrome is an important risk factor for cardiovascular morbidity. Chronic IH, a major component of OSA, is thought to be responsible for most of the cardiovascular complications occurring during OSA, but the underlying...

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Source

Identifiers

PMID: 19358946
DOI: 10.1016/j.jacc.2008.12.050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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