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Article

Hypoxia-Inducible Factor-1 Alpha in the Heart

5 Jun 2012

Abstract excerpt

Hypoxia-inducible factor (HIF) is a set of transcription factors that regulate the cellular response to hypoxia. There is a great body of evidence supporting the protective role of HIF-1α in cardiovascular pathophysiology, however, newer studies are hinting at a maladaptive and deleterious role of this transcription factor that merits further investigation. There is a general agreement, however, that HIF-mediated...

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PMID: 22673235
DOI: 10.1097/crd.0b013e31826287f6

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