Article
Expression of nitric oxide synthase isoforms in hypothalamo-pituitary-adrenal axis during the development of spontaneous hypertension in rats.
Brain research. Molecular brain research - 18 Aug 2005
Häuser Walter, Sassmann Antonia, Qadri Fatimunnisa, Jöhren Olaf, Dominiak Peter
Abstract excerpt
This study was performed to investigate the expression of the major isoforms of nitric oxide synthase mRNA and protein in the hypothalamo-pituitary-adrenal axis (HPA axis) of spontaneously hypertensive rats (SHR) at two different postnatal ages corresponding to the development of genetic hypertension. Using RT-PCR and Western blot techniques, the mRNA and protein levels of neuronal (nNOS), endothelial (eNOS) and...
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