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Article

Beneficial effects of estrogen in a mouse model of cerebrovascular insufficiency.

PloS one - 1 Jan 2009

Kitamura Naohito, Araya Runa, Kudoh Moeko, Kishida Haruo, Kimura Tetsuya, Murayama Miyuki, Takashima Akihiko, Sakamaki Yuriko, Hashikawa Tsutomu, Ito Shingo, Ohtsuki Sumio, Terasaki Tetsuya, Wess Jürgen, Yamada Masahisa

Abstract excerpt

BACKGROUND: The M(5) muscarinic acetylcholine receptor is known to play a crucial role in mediating acetylcholine dependent dilation of cerebral blood vessels. Previously, we reported that male M(5) muscarinic acetylcholine knockout mice (M5R(-/-) mice) suffer from a constitutive constriction of cerebral arteries, reduced cerebral blood flow, dendritic atrophy, and short-term memory loss, without necrosis and/or...

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Source

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Identifiers

PMID: 19357782
DOI: 10.1371/journal.pone.0005159
PMCID: PMC2664330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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