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Article

Estrogen receptor-alpha mediates the brain antiinflammatory activity of estradiol.

Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2003

Vegeto Elisabetta, Belcredito Silvia, Etteri Sabrina, Ghisletti Serena, Brusadelli Alessia, Meda Clara, Krust Andrée, Dupont Sonia, Ciana Paolo, Chambon Pierre, Maggi Adriana

Abstract excerpt

Beyond the key role in reproductive and cognitive functions, estrogens have been shown to protect against neurodegeneration associated with acute and chronic injuries of the adult brain. Current hypotheses reconcile this activity with a direct effect of 17beta-estradiol (E2) on neurons. Here we d...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12878732
DOI: 10.1073/pnas.1531957100
PMCID: PMC170966

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12878732-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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