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Mutant Actins Demonstrate a Role for Unpolymerized Actin in Control of Transcription by Serum Response Factor

1 Dec 2002

Abstract excerpt

Signal-induced activation of the transcription factor serum response factor (SRF) requires alterations in actin dynamics. SRF activity can be inhibited by ectopic expression of beta-actin, either because actin itself participates in SRF regulation or as a consequence of cytoskeletal perturbations. To distinguish between these possibilities, we studied actin mutants. Three mutant actins, G13R, R62D, and a...

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PMID: 12475943
DOI: 10.1091/mbc.02-05-0068

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