Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Profilin1 biology and its mutation, actin(g) in disease.

Cellular and molecular life sciences : CMLS - 1 Mar 2017

Alkam Duah, Feldman Ezra Z, Singh Awantika, Kiaei Mahmoud

Abstract excerpt

Profilins were discovered in the 1970s and were extensively studied for their significant physiological roles. Profilin1 is the most prominent isoform and has drawn special attention due to its role in the cytoskeleton, cell signaling, and its link to conditions such as cancer and vascular hypertrophy. Recently, multiple mutations in the profilin1 gene were linked to amyotrophic lateral sclerosis (ALS). In this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Amyotrophic Lateral Sclerosis Research
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease

Share to Mutation

Share to Neurogenetic and Muscular Disorders Research

Share to Neuronal Plasticity

Share to Profilins

Source

Open in PubMed Open full text

Identifiers

PMID: 27669692
DOI: 10.1007/s00018-016-2372-1
PMCID: PMC5311022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Profilin1 biology and its mutation, actin(g) in disease.PMID 27669692Read ↗

Profilin Isoforms in Health and Disease – All the Same but DifferentSemantic proximity Read ↗

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis.Semantic proximity Read ↗

The Actin Cytoskeleton in SMA and ALS: How Does It Contribute to Motoneuron Degeneration?Semantic proximity Read ↗

The actin binding protein profilin 1 is critical for mitochondria functionSemantic proximity Read ↗

Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity.Semantic proximity Read ↗

Amyotrophic lateral sclerosis-associated mutant profilin 1 increases dendritic arborisation and spine formation in primary hippocampal neurons.Semantic proximity Read ↗

Mammalian Actins: Isoform-Specific Functions and Diseases.Semantic proximity Read ↗

ALS-linked PFN1 variants exhibit loss and gain of functions in the context of formin-induced actin polymerization.Semantic proximity Read ↗

Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron diseaseSemantic proximity Read ↗

Structure and function of profilin.Semantic proximity Read ↗

A Drosophila model of ALS reveals a partial loss of function of causative human PFN1 mutants.Semantic proximity Read ↗

The spinal muscular atrophy gene product regulates actin dynamicsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.