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The Actin Cytoskeleton in SMA and ALS: How Does It Contribute to Motoneuron Degeneration?

1 May 2017

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are neurodegenerative diseases with overlapping clinical phenotypes based on impaired motoneuron function. However, the pathomechanisms of both diseases are largely unknown, and it is still unclear whether they converge on the molecular level. SMA is a monogenic disease caused by low levels of functional Survival of Motoneuron (SMN) protein,...

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PMID: 28459188
DOI: 10.1177/1073858417705059

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