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Article

Active Transport of the Survival Motor Neuron Protein and the Role of Exon-7 in Cytoplasmic Localization

23 Jul 2003

Abstract excerpt

Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by deletion and/or mutation of the survival motor neuron protein Gene (SMN1) that results in the expression of a truncated protein lacking the C terminal exon-7. Whereas SMN has been shown to be an important component of diverse ribonucleoprotein (RNP) complexes, its function in neurons is unknown. We hypothesize that the active transport of SMN...

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Identifiers

PMID: 12878704
DOI: 10.1523/jneurosci.23-16-06627.2003

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