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Article

The extracellular domain of the TGFbeta type II receptor regulates membrane raft partitioning.

The Biochemical journal - 12 Jun 2009

Luga Valbona, McLean Sarah, Le Roy Christine, O'Connor-McCourt Maureen, Wrana Jeffrey L, Di Guglielmo Gianni M

Abstract excerpt

Cell-surface TGFbeta (transforming growth factor beta) receptors partition into membrane rafts and the caveolin-positive endocytic compartment by an unknown mechanism. In the present study, we investigated the determinant in the TGFbeta type II receptor (TbetaRII) that is necessary for membrane raft/caveolar targeting. Using subcellular fractionation and immunofluorescence microscopy techniques, we demonstrated...

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Identifiers

PMID: 19356148
DOI: 10.1042/BJ20081131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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