Article
Cholesterol sensitivity of detergent resistance: a rapid flow cytometric test for detecting constitutive or induced raft association of membrane proteins.
Cytometry. Part A : the journal of the International Society for Analytical Cytology - 1 Oct 2004
Gombos Imre, Bacsó Zsolt, Detre Cynthia, Nagy Henrietta, Goda Katalin, Andrásfalvy Márton, Szabó Gábor, Matkó János
Abstract excerpt
BACKGROUND: Lipid rafts are cholesterol- and glycosphingolipid-rich microdomains in the cellular plasma membranes that play critical roles in compartmentalization (concentration, coupling, and isolation) of receptors and signal molecules. Therefore, detecting constitutive or induced raft associations of such proteins is of central interest in cell biology. This has mostly been done with time- and cell-consuming...
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