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Article

Tubulin: A Target for Antineoplastic Drugs into the Cancer Cells but also in the Peripheral Nervous System

1 Apr 2009

Abstract excerpt

Since the introduction into clinical practice of vinca alkaloids, tubulin has become a key and well-established target of modern antineoplastic chemotherapy. When taxanes became available their broad spectrum of activity was striking and opened up new horizons for cancer patients' treatment. However, taxanes' susceptibility to drug resistance caused by the drug efflux pump protein, P-glycoprotein, is not...

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PMID: 19355888
DOI: 10.2174/092986709787846488

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