Article
Identification of copy number abnormalities and inactivating mutations in two negative regulators of nuclear factor-kappaB signaling pathways in Waldenstrom's macroglobulinemia.
Cancer research - 15 Apr 2009
Braggio Esteban, Keats Jonathan J, Leleu Xavier, Van Wier Scott, Jimenez-Zepeda Victor H, Valdez Riccardo, Schop Roelandt F J, Price-Troska Tammy, Henderson Kimberly, Sacco Antonio, Azab Feda, Greipp Philip, Gertz Morie, Hayman Suzanne, Rajkumar S Vincent, Carpten John, Chesi Marta, Barrett Michael, Stewart A Keith, Dogan Ahmet, Bergsagel P Leif, Ghobrial Irene M, Fonseca Rafael
Abstract excerpt
Waldenström's macroglobulinemia (WM) is a distinct clinicobiological entity defined as a B-cell neoplasm characterized by a lymphoplasmacytic infiltrate in bone marrow (BM) and IgM paraprotein production. Cytogenetic analyses were historically limited by difficulty in obtaining tumor metaphases, and the genetic basis of the disease remains poorly defined. Here, we performed a comprehensive analysis in 42 WM...
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