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Article

Transcriptome sequencing reveals a profile that corresponds to genomic variants in Waldenström macroglobulinemia.

Blood - 11 Aug 2016

Hunter Zachary R, Xu Lian, Yang Guang, Tsakmaklis Nicholas, Vos Josephine M, Liu Xia, Chen Jie, Manning Robert J, Chen Jiaji G, Brodsky Philip, Patterson Christopher J, Gustine Joshua, Dubeau Toni, Castillo Jorge J, Anderson Kenneth C, Munshi Nikhil M, Treon Steven P

Abstract excerpt

Whole-genome sequencing has identified highly prevalent somatic mutations including MYD88, CXCR4, and ARID1A in Waldenström macroglobulinemia (WM). The impact of these and other somatic mutations on transcriptional regulation in WM remains to be clarified. We performed next-generation transcriptional profiling in 57 WM patients and compared findings to healthy donor B cells. Compared with healthy donors, WM...

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Share to B-Lymphocytes
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Myeloid Differentiation Factor 88

Share to Receptors, CXCR4

Share to Transcriptome

Share to V(D)J Recombination

Share to Waldenstrom Macroglobulinemia

Source

Open in PubMed Open full text

Identifiers

PMID: 27301862
DOI: 10.1182/blood-2016-03-708263
PMCID: PMC4982454

Genes

CXCR4
MYD88
AICDA
CXCL12
CXCL13
DNTT
RAG1
RAG2
TLR4
VCAM1

Provenance

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