Article
PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation.
Journal of cell science - 1 May 2009
Zhang Ming, Xie Rong, Hou Wei, Wang Baoli, Shen Run, Wang Xiumei, Wang Qing, Zhu Tianhui, Jonason Jennifer H, Chen Di
Abstract excerpt
In chondrocytes, PTHrP maintains them in a proliferative state and prevents premature hypertrophy. The mechanism by which PTHrP does this is not fully understood. Both Runx2 and Runx3 are required for chondrocyte maturation. We recently demonstrated that cyclin D1 induces Runx2 protein phosphorylation and degradation. In the present studies, we tested the hypothesis that PTHrP regulates both Runx2 and Runx3...
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