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Article

A nucleolar protein allows viability in the absence of the essential ER-residing molecular chaperone calnexin.

Journal of cell science - 1 May 2009

Beauregard Pascale B, Guérin Renée, Turcotte Cynthia, Lindquist Susan, Rokeach Luis A

Abstract excerpt

In fission yeast, the ER-residing molecular chaperone calnexin is normally essential for viability. However, a specific mutant of calnexin that is devoid of chaperone function (Deltahcd_Cnx1p) induces an epigenetic state that allows growth of Schizosaccharomyces pombe without calnexin. This calnexin-independent (Cin) state was previously shown to be mediated via a non-chromosomal element exhibiting some...

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Identifiers

PMID: 19351719
DOI: 10.1242/jcs.040949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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