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Article

Genetic variants in oxidative stress-related genes predict chemoresistance in primary breast cancer: a prospective observational study and validation.

Cancer research - 15 Jan 2012

Yu Ke-Da, Huang A-Ji, Fan Lei, Li Wen-Feng, Shao Zhi-Ming

Abstract excerpt

Chemotherapy response in patients with primary breast cancer is difficult to predict and the role of host genetic factors has not been thoroughly investigated. We hypothesized that polymorphisms in oxidative stress (OS)-related genes, including estrogen-quinone metabolizing enzymes NQO2 and GSTM1-5, may influence disease progression and treatment response. In this prospective observational study, nineteen...

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Source

Identifiers

PMID: 22147260
DOI: 10.1158/0008-5472.CAN-11-2998

Genes

GSTM1
NQO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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