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Article

Lack of association between PRNP 1368 polymorphism and Alzheimer's disease or vascular dementia.

BMC medical genetics - 8 Apr 2009

Jeong Byung-Hoon, Lee Kyung-Hee, Lee Yun-Jung, Kim Yun Joong, Choi Eun-Kyoung, Kim Young-Hoon, Cho Young-Sook, Carp Richard I, Kim Yong-Sun

Abstract excerpt

BACKGROUND: Polymorphisms of the prion protein gene (PRNP) at codons 129 and 219 play an important role in the susceptibility to Creutzfeldt-Jakob disease (CJD), and might be associated with other neurodegenerative disorders. Several recent reports indicate that polymorphisms outside the coding region of PRNP modulate the expression of prion protein and are associated with sporadic CJD, although other studies...

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Identifiers

PMID: 19351416
DOI: 10.1186/1471-2350-10-32
PMCID: PMC2676277

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Lack of association between PRNP 1368 polymorphism and Alzheimer's disease or vascular dementia.PMID 19351416Read ↗

PRNP 1368 polymorphism is not associated with sporadic Creutzfeldt-Jakob disease in the Korean population.Semantic proximity Read ↗

Absence of association between codon 129 and 219 polymorphisms of the prion protein gene and vascular dementia.Semantic proximity Read ↗

Association between the PRNP 1368 polymorphism and the occurrence of sporadic Creutzfeldt-Jakob disease.Semantic proximity Read ↗

No association of prion protein gene polymorphisms with Alzheimer's disease in Korean population.Semantic proximity Read ↗

Genotype patterns and characteristics of PRNP in the Korean population.Semantic proximity Read ↗

Is M129V of PRNP gene associated with Alzheimer's disease? A case-control study and a meta-analysis.Semantic proximity Read ↗

Polymorphisms of the prion protein gene (PRNP) in a Korean population.Semantic proximity Read ↗

Polymorphisms at codons 56 and 174 of the prion-like protein gene (PRND) are not associated with sporadic Creutzfeldt-Jakob disease.Semantic proximity Read ↗

Codon 129 polymorphism of prion protein gene in sporadic Alzheimer's disease.Semantic proximity Read ↗

The association between the methionine/valine (M/V) polymorphism (rs1799990) in the PRNP gene and the risk of Alzheimer disease: an update by meta-analysis.Semantic proximity Read ↗

[The relationship between prion protein gene codon 129 polymorphism and Alzheimer's disease].Semantic proximity Read ↗

The influence of PRNP polymorphisms on human prion disease susceptibility: an update.Semantic proximity Read ↗

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