Article
Polymorphisms of the prion protein gene (PRNP) in a Korean population.
Journal of human genetics - 1 Jan 2004
Jeong Byung-Hoon, Nam Jae-Hwan, Lee Yun-Jung, Lee Kyung-Hee, Jang Myoung-Kuk, Carp Richard I, Lee Ho-Dong, Ju Young-Ran, Ahn Jo Sangmee, Park Keun-Yong, Kim Yong-Sun
Abstract excerpt
Human prion protein gene (PRNP) has been considered to be involved in the susceptibility of humans to prion diseases. Polymorphisms of methionine (Met)/valine (Val) at codon 129 and of glutamic acid (Glu)/lysine (Lys) at codon 219 are thought to play an important role in susceptibility to sporadic, iatrogenic and variant Creutzfeldt-Jakob disease (CJD). Although the genotype distribution of polymorphisms in PRNP...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Codon
- Gene Frequency
- Genotype
- Glutamic Acid
- Heterozygote
- Homozygote
- Humans
- Korea
- Lysine
- Methionine
- Molecular Sequence Data