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Article

In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment.

BMC neuroscience - 7 Apr 2009

Westman Eric, Spenger Christian, Oberg Johanna, Reyer Henry, Pahnke Jens, Wahlund Lars-Olof

Abstract excerpt

BACKGROUND: Donepezil improves cognitive functions in AD patients. Effects on the brain metabolites N-acetyl-L-aspartate, choline and myo-inositol levels have been reported in clinical studies using this drug. The APP/PS1 mouse coexpresses the mutated forms of human beta-amyloid precursor protein (APP) and mutated human presenilin 1 (PS1). Consequently, the APP/PS1 mouse model reflects important features of the...

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Identifiers

PMID: 19351388
DOI: 10.1186/1471-2202-10-33
PMCID: PMC2674598

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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