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Article

De novo design of a beta alpha beta motif.

Angewandte Chemie (International ed. in English) - 1 Jan 2009

Liang Huanhuan, Chen Hao, Fan Keqiang, Wei Ping, Guo Xianrong, Jin Changwen, Zeng Chen, Tang Chao, Lai Luhua

Abstract excerpt

A designer monomeric protein with a beta alpha beta fold--two parallel beta strands connected by an alpha helix (see structure)--was constructed solely from coded amino acids. The high thermal stability of the structure is due to a large extent to tryptophan-tryptophan interactions between the two beta strands.

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Identifiers

PMID: 19347908
DOI: 10.1002/anie.200805476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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