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Article

High-resolution protein design with backbone freedom.

Science (New York, N.Y.) - 20 Nov 1998

Harbury P B, Plecs J J, Tidor B, Alber T, Kim P S

Abstract excerpt

Recent advances in computational techniques have allowed the design of precise side-chain packing in proteins with predetermined, naturally occurring backbone structures. Because these methods do not model protein main-chain flexibility, they lack the breadth to explore novel backbone conformations. Here the de novo design of a family of alpha-helical bundle proteins with a right-handed superhelical twist is...

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Identifiers

PMID: 9822371
DOI: 10.1126/science.282.5393.1462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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