Article
Computer-aided design of beta-sheet peptides.
Journal of molecular biology - 7 Sept 2001
López de la Paz M, Lacroix E, Ramírez-Alvarado M, Serrano L
Abstract excerpt
The design of beta-sheet proteins is still a challenge in the field of de novo protein design. Here, we have tested the validity of automatic design methods to create and/or improve beta-sheet peptides and proteins. We chose Betanova, a three-stranded beta-sheet peptide, as target system, and, as an automatic design tool, a protein design algorithm called PERLA (protein engineering rotamer library algorithm)....
Topics
- Algorithms
- Amino Acid Sequence
- Circular Dichroism
- Drug Design
- Magnetic Resonance Spectroscopy
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Peptides
- Predictive Value of Tests
- Protein Conformation