Article
Genetic variation in the vitamin C transporter, SLC23A2, modifies the risk of HPV16-associated head and neck cancer.
Carcinogenesis - 1 Jun 2009
Chen Alyce A, Marsit Carmen J, Christensen Brock C, Houseman E Andrés, McClean Michael D, Smith Judith F, Bryan Janine T, Posner Marshall R, Nelson Heather H, Kelsey Karl T
Abstract excerpt
Human papillomavirus (HPV) type 16 infection is an etiologic factor in a subset of head and neck squamous cell carcinomas (HNSCC). It is unknown if host genetic susceptibility modifies the HPV16-HNSCC association. DNA samples collected as part of a Boston area case-control study of HNSCC were genotyped for single-nucleotide polymorphisms (SNPs) from the National Cancer Institute's SNP500Cancer database. Analysis...
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