Article
A coding variant in TMC8 (EVER2) is associated with high risk HPV infection and head and neck cancer risk.
PloS one - 1 Jan 2015
Liang Caihua, Kelsey Karl T, McClean Michael D, Christensen Brock C, Marsit Carmen J, Karagas Margaret R, Waterboer Tim, Pawlita Michael, Nelson Heather H
Abstract excerpt
HPV infection is a causal agent in many epithelial cancers, yet our understanding of genetic susceptibility to HPV infection and resultant cancer risk is limited. Epidermodysplasia Verruciformis is a rare condition of extreme susceptibility to cutaneous HPV infection primarily attributable to mutations in TMC6 and TMC8. Genetic variation in the TMC6/TMC8 region has been linked to beta-type HPV infection and...
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