Article
Genetic evidence for the requirement of the endocytic pathway in the uptake of coenzyme Q6 in Saccharomyces cerevisiae.
Biochimica et biophysica acta - 1 Jun 2009
Padilla-López Sergio, Jiménez-Hidalgo María, Martín-Montalvo Alejandro, Clarke Catherine F, Navas Plácido, Santos-Ocaña Carlos
Abstract excerpt
Coenzyme Q is an isoprenylated benzoquinone lipid that functions in respiratory electron transport and as a lipid antioxidant. Dietary supplementation with Q is increasingly used as a therapeutic for treatment of mitochondrial and neurodegenerative diseases, yet little is known regarding the mechanism of its uptake. As opposed to other yeast backgrounds, EG103 strains are unable to import exogenous Q(6) to the...
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