Article
A chemical chaperone, sodium 4-phenylbutyric acid, attenuates the pathogenic potency in human alpha-synuclein A30P + A53T transgenic mice.
Parkinsonism & related disorders - 1 Nov 2009
Ono Kazuhiko, Ikemoto Miyuki, Kawarabayashi Takeshi, Ikeda Masaki, Nishinakagawa Takuya, Hosokawa Masato, Shoji Mikio, Takahashi Mitsuo, Nakashima Manabu
Abstract excerpt
Aggregation and cytotoxicity of misfolded alpha-synuclein are postulated to be crucial in the disease processes of Parkinson's disease (PD) and other synucleinopathies. Mutations in the alpha-synuclein gene in some pedigrees of familial PD have been reported. The mutant alpha-synuclein has been reported to form fibrillar aggregates resulting in biochemical abnormalities that are responsible for the onset of...
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