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Article

Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice.

ACS chemical neuroscience - 20 Jan 2016

Finkelstein David I, Hare Dominic J, Billings Jessica L, Sedjahtera Amelia, Nurjono Milawaty, Arthofer Elisa, George Sonia, Culvenor Janetta G, Bush Ashley I, Adlard Paul A

Abstract excerpt

The abnormal accumulation of alpha-synuclein (α-syn) has been linked to a number of neurodegenerative disorders, the most noteworthy of which is Parkinson's disease. Alpha-synuclein itself is not toxic and fulfills various physiological roles in the central nervous system. However, specific types of aggregates have been shown to be toxic, and metals have been linked to the assembly of these toxic aggregates. In...

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PMID: 26481462
DOI: 10.1021/acschemneuro.5b00253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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