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Article

Replicative potential of human natural killer cells.

British journal of haematology - 1 Jun 2009

Fujisaki Hiroyuki, Kakuda Harumi, Imai Chihaya, Mullighan Charles G, Campana Dario

Abstract excerpt

The replicative potential of human CD56(+) CD3(-) natural killer (NK) cells is unknown. We found that by exposing NK cells to the leukaemic cell line K562 genetically modified to express 4-1BB ligand and interleukin 15 (K562-mb15-41BBL), they expanded for up to 30 population doublings, achieving numbers that ranged from 1.6 x 10(5) to 1.2 x 10(11)% (median, 5.9 x 10(6)%; n = 7) of those originally seeded....

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Identifiers

PMID: 19344420
DOI: 10.1111/j.1365-2141.2009.07667.x
PMCID: PMC2776622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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