Article
Tumor recognition and self-recognition induce distinct transcriptional profiles in antigen-specific CD4 T cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2009
Getnet Derese, Maris Charles H, Hipkiss Edward L, Grosso Joseph F, Harris Timothy J, Yen Hung-Rong, Bruno Tullia C, Wada Satoshi, Adler Adam, Georgantas Robert W, Jie Chunfa, Goldberg Monica V, Pardoll Drew M, Drake Charles G
Abstract excerpt
Tumors express a wide variety of both mutated and nonmutated Ags. Whether these tumor Ags are broadly recognized as self or foreign by the immune system is currently unclear. Using an autochthonous prostate cancer model in which hemagglutinin (HA) is specifically expressed in the tumor (ProHA x TRAMP mice), as well as an analogous model wherein HA is expressed in normal tissues as a model self-Ag (C3HA(high)), we...
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