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Article

Recognition of a Ubiquitous Self Antigen by Prostate Cancer-Infiltrating CD8 <sup>+</sup> T Lymphocytes

10 Jan 2008

Abstract excerpt

Substantial evidence exists that many tumors can be specifically recognized by CD8+ T lymphocytes. The definition of antigens targeted by these cells is paramount for the development of effective immunotherapeutic strategies for treating human cancers. In a screen for endogenous tumor-associated T cell responses in a primary mouse model of prostatic adenocarcinoma, we identified a naturally arising CD8+ T cell...

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PMID: 18187659
DOI: 10.1126/science.1148886

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