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DNA Replication Licensing and Progenitor Numbers Are Increased by Progesterone in Normal Human Breast

2 Apr 2009

Abstract excerpt

Proliferation in the nonpregnant human breast is highest in the luteal phase of the menstrual cycle when serum progesterone levels are high, and exposure to progesterone analogues in hormone replacement therapy is known to elevate breast cancer risk, yet the proliferative effects of progesterone in the human breast are poorly understood. In a model of normal human breast, we have shown that progesterone increased...

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Identifiers

PMID: 19342456
DOI: 10.1210/en.2008-1630

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