Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women.

doi:10.1186/s13073-022-01063-5

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Article

Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women.

Genome medicine - 15 Jun 2022

Bartlett Thomas E, Evans Iona, Jones Allison, Barrett James E, Haran Shaun, Reisel Daniel, Papaikonomou Kiriaki, Jones Louise, Herzog Chiara, Pashayan Nora, Simões Bruno M, Clarke Robert B, Evans D Gareth, Ghezelayagh Talayeh S, Ponandai-Srinivasan Sakthivignesh, Boggavarapu Nageswara R, Lalitkumar Parameswaran G, Howell Sacha J, Risques Rosa Ana, Rådestad Angelique Flöter, Dubeau Louis, Gemzell-Danielsson Kristina, Widschwendter Martin

Abstract excerpt

BACKGROUND: Breast cancer is a leading cause of death in premenopausal women. Progesterone drives expansion of luminal progenitor cells, leading to the development of poor-prognostic breast cancers. However, it is not known if antagonising progesterone can prevent breast cancers in humans. We suggest that targeting progesterone signalling could be a means of reducing features which are known to promote breast...

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Identifiers

PMID: 35701800
DOI: 10.1186/s13073-022-01063-5
PMCID: PMC9199133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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