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Article

CFAP61 is required for sperm flagellum formation and male fertility in human and mouse

18 Nov 2021

Abstract excerpt

Defects in the structure or motility of cilia and flagella may lead to severe diseases such as primary ciliary dyskinesia (PCD), a multisystemic disorder with heterogeneous manifestations affecting primarily respiratory and reproductive functions. We report that CFAP61 is a conserved component of the calmodulin- and radial spoke-associated complex (CSC) of cilia. We find that a CFAP61 splice variant, c.143+5G>A,...

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PMID: 34792097
DOI: 10.1242/dev.199805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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CFAP61 is required for sperm flagellum formation and male fertility in human and mousePMID 34792097Read ↗

CFAP61 is required for sperm flagellum formation and male fertility in human and mouseSemantic proximity Read ↗

Biallelic Variants in CFAP61 Cause Multiple Morphological Abnormalities of the Flagella and Male InfertilitySemantic proximity Read ↗

Biallelic mutations in CFAP65 cause male infertility with multiple morphological abnormalities of the sperm flagella in humans and miceSemantic proximity Read ↗

A novel mutation in CFAP58 leads to MMAF in humans and mice by disrupting CP assembly.Semantic proximity Read ↗

The cilia and flagella associated protein CFAP52 orchestrated with CFAP45 is required for sperm motility in miceSemantic proximity Read ↗

A novel recurrent mutation in CFAP47 causes male infertility with asthenoteratozoospermiaSemantic proximity Read ↗

Genetic causes of male infertility: snapshot on morphological abnormalities of the sperm flagellumSemantic proximity Read ↗

Biallelic mutations of CFAP74 may cause human primary ciliary dyskinesia and MMAF phenotype.Semantic proximity Read ↗

Biallelic CFAP61 variants cause male infertility in humans and mice with severe oligoasthenoteratozoospermiaSemantic proximity Read ↗

Biallelic variants in MAATS1 encoding CFAP91, a calmodulin-associated and spoke-associated complex protein, cause severe astheno-teratozoospermia and male infertility.Semantic proximity Read ↗

A novel homozygous CFAP65 mutation in humans causes male infertility with multiple morphological abnormalities of the sperm flagellaSemantic proximity Read ↗

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