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Article

A role for the FEAR pathway in nuclear positioning during anaphase.

Developmental cell - 1 May 2004

Ross Karen E, Cohen-Fix Orna

Abstract excerpt

In budding yeast, cells lacking separase function exit mitosis with an undivided nucleus localized to the daughter cell. Here we show that the inability to separate sister chromatids per se is not sufficient to cause the daughter preference. Rather, separase affects nuclear positioning as part of the Cdc14 early anaphase release (FEAR) pathway. The role of the FEAR pathway in nuclear positioning is exerted during...

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Identifiers

PMID: 15130497
DOI: 10.1016/s1534-5807(04)00128-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A role for the FEAR pathway in nuclear positioning during anaphase.PMID 15130497Read ↗

Cdc14 inhibition by the spindle assembly checkpoint prevents unscheduled centrosome separation in budding yeast.Semantic proximity Read ↗

Nucleolar segregation lags behind the rest of the genome and requires Cdc14p activation by the FEAR network.Semantic proximity Read ↗

Cdc14 and condensin control the dissolution of cohesin-independent chromosome linkages at repeated DNA.Semantic proximity Read ↗

Cdc14 Early Anaphase Release, FEAR, Is Limited to the Nucleus and Dispensable for Efficient Mitotic Exit.Semantic proximity Read ↗

The Cdc14 phosphatase and the FEAR network control meiotic spindle disassembly and chromosome segregation.Semantic proximity Read ↗

Slk19p of Saccharomyces cerevisiae regulates anaphase spindle dynamics through two independent mechanisms.Semantic proximity Read ↗

Cdc14p/FEAR pathway controls segregation of nucleolus in S. cerevisiae by facilitating condensin targeting to rDNA chromatin in anaphase.Semantic proximity Read ↗

The MEN mediates the effects of the spindle assembly checkpoint on Kar9-dependent spindle pole body inheritance in budding yeast.Semantic proximity Read ↗

FEAR but not MEN genes are required for exit from meiosis I.Semantic proximity Read ↗

Regulation of Spo12 phosphorylation and its essential role in the FEAR network.Semantic proximity Read ↗

Lte1 promotes mitotic exit by controlling the localization of the spindle position checkpoint kinase Kin4.Semantic proximity Read ↗

Cdc14 phosphatase induces rDNA condensation and resolves cohesin-independent cohesion during budding yeast anaphase.Semantic proximity Read ↗

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