Article
Novel linkage disequilibrium of single nucleotide polymorphisms in the transcriptional regulatory region of micro-opioid receptor gene in Japanese population.
Biological & pharmaceutical bulletin - 1 Apr 2009
Ono Takeshi, Muto Akihiro, Kaneda Toshio, Arita Eri, Yoshida Tadashi
Abstract excerpt
micro-Opioid receptor agonists, such as morphine, are widely applied in pain therapy clinical practice. However, the effects exerted by morphine via receptor are influenced by individual specificity. Single nucleotide polymorphisms (SNPs) in micro-opioid receptor gene (OPRM1) have been reported to influence receptor expression and function. Subsequently, we analyzed SNPs frequency and linkage disequilibrium...
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