Article
Haplotype block structure of the genomic region of the mu opioid receptor gene.
Journal of human genetics - 1 Feb 2011
Levran Orna, Awolesi Olaoluwakitan, Linzy Shirley, Adelson Miriam, Kreek Mary Jeanne
Abstract excerpt
The opioid system is involved in the action of opiate drugs, opioid addiction, pain experience and analgesia. Individual differences in opioid effect may be attributed in part to genetic variations. Long-range cis regulatory elements and intronic variants are potential sources of functional diversity. Recently, we have detected association of two intronic OPRM1 variants with heroin addiction in European...
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