Article
Association of μ-opioid receptor gene (OPRM1) haplotypes with postoperative nausea and vomiting.
Experimental brain research - 1 Aug 2014
Sugino Shigekazu, Hayase Tomo, Higuchi Misako, Saito Katsuhiko, Moriya Hiroyuki, Kumeta Yukihiro, Kurosawa Nahoko, Namiki Akiyoshi, Janicki Piotr K
Abstract excerpt
Genetic variants, such as single-nucleotide polymorphisms (SNPs), of the μ-opioid receptor gene (OPRM1) might be associated with individual differences in opioid sensitivity, as well as with the incidence and severity of postoperative nausea and vomiting (PONV). The goal of the present study was to determine, in a cohort of Japanese surgical patients, genotypes and haplotypes of several SNPs in the OPRM1 gene,...
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