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Emerging role of VCP/p97 in cardiovascular diseases: novel insights and therapeutic opportunities.

Biochemical Society transactions - 26 Feb 2021

Shu Hongyang, Peng Yizhong, Hang Weijian, Zhou Ning, Wang Dao Wen

Abstract excerpt

Valosin-containing protein (VCP/p97) is a member of the conserved type II AAA+ (ATPases associated with diverse cellular activities) family of proteins with multiple biological functions, especially in protein homeostasis. Mutations in VCP/p97 are reportedly related to unique autosomal dominant diseases, which may worsen cardiac function. Although the structure of VCP/p97 has been clearly characterized, with...

Topics

Animals
Cardiovascular Diseases
Humans
Molecular Targeted Therapy
Mutation
Valosin Containing Protein

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33439255
DOI: 10.1042/BST20200981
PMCID: PMC7925001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Emerging role of VCP/p97 in cardiovascular diseases: novel insights and therapeutic opportunities.PMID 33439255Read ↗

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