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Article

CTLA4/ICOS gene variants and haplotypes are associated with rheumatoid arthritis and primary biliary cirrhosis in the Canadian population.

Arthritis and rheumatism - 1 Apr 2009

Walker Erin J, Hirschfield Gideon M, Xu Chun, Lu Yan, Liu Xiangdong, Lu Yue, Coltescu Catalina, Wang Kesheng, Newman William G, Bykerk Vivian, Keystone Edward C, Mosher Dianne, Amos Christopher I, Heathcote E Jenny, Siminovitch Katherine A

Abstract excerpt

OBJECTIVE: The co-occurrence of different autoimmune diseases in patients and their families suggests the presence of shared genetic risk factors. Two compelling candidate autoimmune disease susceptibility genes are those that encode CTLA4 and inducible costimulator (ICOS), immunoregulatory proteins. Associations of CTLA4 polymorphisms with various autoimmune diseases have been reported, but for rheumatoid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19333938
DOI: 10.1002/art.24412

Genes

CTLA4
ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CTLA4/ICOS gene variants and haplotypes are associated with rheumatoid arthritis and primary biliary cirrhosis in the Canadian population.PMID 19333938Read ↗

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